Wednesday, 22 April 2020

POSITION PAPER

POSITION PAPER
Health workers’ rights in the time of COVID-19
by Jan Swasthya Abhiyan (JSA), All India People's Science Network (AIPSN) and
Public Services International India National Coordination Committee (PSI India NCC)
21 April 2020
Introduction
As of 21 April, the COVID-19 pandemic has infected about 2,482,158 people worldwide and
contributed to 170,470 deaths. In India as on 20 April, the number of people infected with COVID-
19 is 17,656 with 559 deaths. The corona virus Sars-CoV-2 that causes COVID-19 is potent for certain
biological reasons―its structure enables it to latch on to hosts easily, it has a long infection
period, it is infectious even in asymptomatic carriers, and human beings have no immunity to it as
yet. Hence it can spread easily and quickly. A large, sudden influx of patients can put extreme stress
on both the healthcare system in India and on its health workers, as we are currently witnessing in
many countries in Europe and the United States. Health workers are generally at high risk. In Italy
for instance, it has been reported a staggeringly high proportion of all those infected are healthcare
workers. India is witnessing an increasing number of cases of infection among health workers.
The situation is made worse by the fact that COVID-19 has hit India against the backdrop of
a neoliberal assault on healthcare. This assault has meant that public health facilities are in disrepair,
neglected, and overburdened. At the same time, private hospitals and nursing homes have proliferated,
without adequate regulation.
The main rationale for the poorly planned 27-day lockdown and its extension upto 3 May by
many states, with disastrous effects on lakhs of informal and migrant workers, is that it will buy
time for the government to prepare for COVID-19’s likely assault. However, governments’ actions
till now have been both late and inadequate. The current situation is dire. Testing is inadequate,
there is severe scarcity of test kits and the much-publicized antibody-based kits have barely begun
trickling in, more ventilators are needed, and the availability of personal protective equipment
(PPE) is poor and uneven across regions and hospitals. Moreover, the high population density in
slum settlements and bastis in all towns of India makes physical distancing, even in a period of
lockdown, impossible and puts the poor and a very large number of workers at risk of infection.
Additionally, health facilities can become sources of the spread of infection, with three concentric
circles of risk: individual health workers in direct contact with patients; other employees including
fellow-nurses, doctors, and other health workers; and three, the public coming to a hospital.
Recent episodes, such as in Delhi, Mumbai, and Hyderabad have shown that this can occur at any
health facility, not just at COVID-19-identified ones, particularly given that the current Indian testing
and patient management protocol has no provision for testing symptomatic patients without a
contact history and isolating those who are positive but asymptomatic. These patients might have
high infectivity and will be coming into close contact with many healthcare providers without either
patient or health providers knowing. There are also asymptomatic carriers in the public, many of
whom will be seeking care due to co-morbidities. Health workers at the community level, such as
ASHAs, who are deployed either for Covid-19 outreach and community awareness or for routine
community level work such as immunisation, are also facing higher risk of exposure to the virus.
Hence, the rights and protection against risk of health workers on the one hand, and the robustness
of the health system on the other, and the policies with regard to testing, all deeply intersect in the
times of COVID-19.
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Because health workers are on the frontlines of our response to COVID-19, they face higher
risks of infection, overwork, and stress. Hence, any strategy to fight the pandemic should consider
the rights and protection of health workers, including through the following:
(a) adequate PPE should be provided;
(b) access to testing and treatment needs to be ensured;
(c) health workers should be covered for COVID-19-related sick leave, quarantine and
provided compensation;
(d) workers should be allowed to opt out of performing their work in conditions that puts
them at risk, without risk of losing their jobs;
(e) proper training needs to be provided regarding procedures before workers are deployed;
(f) representatives of health workers need to be actively involved in setting up safeguard
measures in health facilities;
(g) the organization of work in hospitals (such as patient flow in the outpatient wards)
should be such that their risk of exposure to healthcare workers is minimized;
(h) wages and overtime should be paid as per the law without any mandatory or so-called
voluntary cuts;
(i) adequate facilities should be provided across needs such as adequate accommodation,
transportation, child care, and nutritious meals;
(j) measures are urgently required to protect health workers against stigma, violence, discrimination,
and sexual harassment;
(k) existing vacancies need to be filled with a long-term perspective;
The COVID-19 crisis and the effectiveness of health systems response both in India and
globally, clearly underlines the need for healthcare to be in the public sector. The related, broader issues
of health workers’ employment, equal pay for equal work, and rights to occupational health
and safety and better working conditions is central for countries to be able to cope with COVID-19
now. We welcome the broader support and appreciation for the work that health workers are doing
in the forefront in the fight against COVID-19. However, just appreciation and statements of good
intent are not enough. Nor are simply clapping hands and banging plates. We need this support to be
legalized through notifications and legislation by the appropriate authority at varied levels of government:
centre, state, and local bodies. How robust we make the healthcare system and strengthen
all health workers now is central to coping better not just with the present crisis, but how well we
will be able to cope with any health crises in the future.
A precarious health workforce makes the health system more fragile
The continuous underfunding of public healthcare has meant that in public hospitals, due to
budgetary tightening, vacancies of health professionals―from doctors, to nurses to
paramedics―have not been filled. This imposes a heavy workload on the existing staff that was
already hard for them to manage. In many facilities, especially under local bodies and poorer state
governments, professional staff shortages have been dealt with by hiring on short-term contracts or
deploying field staff in hospital settings, such as with ANMs. Health workers who are ‘non-professionals’,
such as ward attendants and housekeeping staff, cleaning and security staff are most often
hired through contractors, at low wages, pathetic working conditions, and too often in violation of
the labour law.
While the private health sector has thrived and expanded, its workforce is highly underpaid,
except for high profile and specialised doctors. Across the country, nurses in private hospitals are, at
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best, paid around the minimum wage for a skilled worker, and most often below this legal benchmark.
This sets the scale for other staff, who also face the challenge of being hired through a third
party which makes their tenure highly insecure and without social security coverage.
The workforce at the primary level of care provided in health posts and at the community
level are unarguably the most neglected. Field/community health workers, such as the Accredited
Social Health Activists (ASHAs) in rural settings or Community Health Volunteers (CHVs) in
Mumbai, are the largest group of health workers with more than 9 lakh workers in India. They are
denied the status of a worker by the State. ASHAs are told they are ‘volunteer’ activists and not
workers of the health system, thus denied minimum wage and any other rights of a worker under the
law.
As health workers across the health system have been mobilised to respond to the pandemic,
the pre-existing cracks and weaknesses in the system make it all the more fragile. Informal employment
leads to unclear responsibilities towards workers, and has created blind spots in the system.
ASHAs and CHVs have been deployed for case identification without adequate safeguards. Sanitation
and support staff who are contractual are being preferentially deployed as compared to regular
staff, so as to avoid social security obligations in case of their illness. Public hospitals will be at the
centre of the response to the COVID-19 epidemic, but they will have to be reinforced by private facilities,
either through collaboration, or preferably, through requisition by the government. The precariousness
faced by the vast majority of the close to 40 lakh health workers has to be addressed as
a matter of priority as part of health system preparedness that the lockdown is meant to enable.
Previous outbreaks of highly infectious communicable diseases have demonstrated that public
health outcomes are significantly improved when labour rights are respected, and trade unions
are able to effectively represent workers actually exposed and potentially exposed to the disease.
The active involvement of health workers’ representatives in government decision-making is necessary
to safeguard workplace safety and health and ensure the cost of the crisis is not borne by
healthcare personnel.
REQUIRED MEASURES
a) Adequate provisioning of Personal Protective Equipment
Reports coming in from Maharashtra, West Bengal, Tamil Nadu, and Bihar point to uneven availability
of PPE of adequate quality, leading to protests. Workers are worried that raincoats are provided
instead of medical gowns, that eye protection and other equipment has not been provided. Workers
are forced to do risky procedures without proper PPE, or asked to quit if they refuse. This is creating
confusion on stress amongst the health workforce and needs to be urgently addressed.
The guidelines of the government of India - that make recommendations regarding the use of specific
PPE for different categories of workers, including medical masks, gloves, gowns, eye protection,
and footwear and respirators depending on the kinds of patient care - have not been adhered to.
Even the WHO interim guidance of 19 March 2020 on Rational Use of PPE for coronavirus disease
(COVID-19) have not been followed. New guidelines (dated 20 April) acknowledge the risk of
infection by asymptomatic patients who visit a health facility for other health reasons, yet they do
not provide guidance on PPE requirements. We recommend that the Indian government ensures systems
to monitor and enforce strict adherence to adequate guidelines for the use of PPE.
There has been a clear and criminal lack of preparedness and stockpiling, in disregard of WHO
guidelines of 27 February 2020. The Ministry of Health has admitted a shortage of equipment and
supply not meeting rising demand. This is compounded by an inadequate estimate of the size of the
health workforce, which the government estimates at 22 lakh, while it should be closer to 40 lakh1.
1A 2016 estimate suggests that the number of health professionals and para professionals alone (including doctors,
nurses and midwives, dentists, laboratory technicians and paramedics) was close to 25.3 lakh. The latter does not
include health workers such as cleaning staff, ward attendants, ambulance drivers, ASHAs and ANMs, to name a few.
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Given the uneven nature of PPE availability across regions, we recommended that PPE be sourced
in priority from domestic manufacturers with a long-term view of development of domestic industrial
capability, and supplied to deal with clusters of cases as they occur. This implies that PPE procurement
orders have to be increased to ensure adequate access to all health workers, and PPE be
sent to regions where they are most needed.
The shortage of necessary PPE equipment and the traditional structures of social discrimination in
India could lead to certain categories of workers, such as nurses who are at highest risk, but also
ASHAs, non-permanent/contract workers and cleaners, not being provided adequate PPE. We urge
that the government issue a directive that no such discrimination take place against any worker in
any establishment. Health workers should not be forced to work under unsafe conditions without
adequate protective equipment.
b) Free health care for all health workers
The announcement by the Finance Minister of a special life insurance scheme for health workers is
misleading and insufficient. Despite an announcement that all health workers would be covered, the
package covers health workers in the private sector only if they are drafted for COVID-19
responsibilities. The recent case of health workers getting infected at the private facility Delhi State
Cancer Institute shows that this is insufficient. Further, this is subject to the numbers indicated by
MoHFW. The figure of 22 lakh health workers is a gross underestimation of the actual size of the
workforce in the country, as mentioned earlier. The estimate should be modified correspondingly
and increased to at least 40 lakh health workers and the omission of healthcare workers in the
private sectors needs to be corrected immediately to avoid the possibility of denial of compensation.
Most importantly, this scheme is grossly insufficient as it does not provide any support to health
workers and their families unless the worker dies. In case health workers are infected by COVID-19
they should be given treatment, care and support free of cost. Considering that health workers in
informal employment conditions are more vulnerable as employers can hide behind this informality
to deny their responsibility towards them, it is important that they are given special attention in this
regard. The latest testing protocol (31 March) has expanded testing only to symptomatic health care
workers, whereas there is clear evidence of asymptomatic cases. As current testing protocols are
restrictive, health workers might find that they are compelled to go for testing in private labs, and
incur costs. Failure to detect infections early among healthcare workers may result in further
spreading of the infection. Access to comprehensive and free health care, including outpatient,
hospitalisation, and regular free testing need to be ensured, with special attention to informal
health workers. Special provision of regular testing needs to be ensured for health workers
performing high risk tasks, even if asymptomatic.
c) Special COVID-19 related paid leave and compensation
Health workers are at a higher risk of contracting infectious diseases, which is the case with
COVID-19 as well. Reports estimate close to 100 infections already confirmed in India, though
there is no systematic reporting of this data. As facilities are short-staffed, managements of facilities
are extending working hours. They might try to keep health workers on the job even when they are
already showing COVID-19-like symptoms, as we saw in Mumbai and in Bihar. Workers who have
tested positive with COVID-19 should not be asked to continue with their duties if they are showing
symptoms. This is against protocols and puts the workers at more risk of developing more severe
symptoms if they are not able to rest adequately.
Managements of facilities might also deduct leave taken for sickness or quarantine from existing
leave provisions, and when these are used up, take recourse to cutting workers’ wages. Informal
ASHAs alone are estimated to around 8.5 lakh, ANMs to around 2 lakh. While there is no estimate available for
ancillary health staff, it is safe to presume that at least 2 to 4 lakh, bringing the total number close to 40 lakh/4 million.
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workers have a limited amount of paid leave that will run out quickly. Those on daily wages do not
even have paid leave. Special paid leave in case of COVID-19-related sickness and quarantine
should be provided, including to workers on short-term contracts and employed through a third
party. A special compensation should also be announced for health workers who contract COVID-
19 in line with the WHO definition that if exposure to corona virus Sars-CoV-2 happens at the
workplace, contracting COVID-19 should be considered an occupational disease.
d) Mental health support and the right to opt out
Health workers undergo considerable stress during emergencies such as the one we are facing.
Counselling and mental health support should be made available for health workers. Breaks and
time-off should be maintained, as healthcare workers' burnout could contribute to both their
catching the virus and its spread. As per WHO guidelines, health workers should not be required to
return to a work situation where there is continuous or serious danger to their life or health. Health
workers' right to opt out of work when they are not provided with a safe working environment and
adequate protective equipment should be respected, without undue consequences.
Health workers who are pregnant, or have co-morbidities have higher chances to contract the
infection and develop more severe symptoms. They should not be put on duty in the COVID-19
ward and limit exposure to patients with suspected COVID-19. Instead, they should be assigned
appropriate tasks within their profession that does not expose them the virus and be accommodated
if they request so.
e) Training on procedures and infection risk management
Managing the risk of infection in health facilities, both in the public and private sectors, is essential
to ensure that health facilities do not themselves become hubs of infection. Part of the risk
management procedure is to ensure that all health workers understand the measures that are needed
to protect themselves, protect patients, and protect the facility. The government should implement or
direct facilities to implement appropriate training for the diversity of workers categories across
levels of risk.
The government needs to put in place online training programmes on infection control with a focus
on COVID-19 for the entire medical workforce in the country, facility-based training for the entire
workforce in each facility, including ASHA and community-based health workers attached to
different health posts. All health workers should be provided with communication materials in
different languages on the appropriate safeguards, including but not limited to PPEs.
The entire staff in all COVID-19 earmarked hospitals, ICU units, and isolation centres should be
given training and this should include both guidelines and protocols for COVID-19 care, as well as
personal safety, infection risk management and the use of personal protective equipment. The
government should provide guidelines for these procedures to be followed in private facilities. A
helpline should be set up for health workers who face challenges at their workplace, with a defined
procedure to register complaints and interventions to resolve them. In case private facilities fail to
follow the government guidelines and resolve issues with regard to adequate safeguard measures,
the state government should consider requisitioning these private facilities in order to avoid the
spread of the disease due to negligence of private operators.
f) Active involvement of representatives of health workers
The government should engage with trade unions of health workers to ensure that the guidelines effectively
reach all concerned health workers. For instance, there is a need for clear information and
training regarding PPE use, disposal, and care. Health worker unions are well positioned to contrib-
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ute to this process, as they have the organizational ability to reach out to large sections of workers
quickly. Hence, we urge that different state governments involve health worker unions in the process
of information-sharing, training, and workers’ safety. Facility management should facilitate an
active role for health workers' representatives in determining safety measures and safeguards of
their health.
(g) organization of work in hospitals that minimises risk of exposure to healthcare workers
The other part of risk protection is the proper organization of work processes that would limit hospital
infection to patients as well as to (all) health workers. This is a part of most quality accreditation
programmes, such as the national quality assurance standards for public health facilities and
multiple systems for private healthcare facilities. However, only a small proportion of facilities are
registered under these frameworks. One of the reasons why Kerala has reported fewer infections
among workers and less spread of the virus overall is because it has much better level of accreditation
and infection control. The infection control component of the quality accreditation programmes
must be implemented universally across states, including in the private sector, along with a monitoring
mechanism by the government.
h) Wages and extra-time to be remunerated as per the law
As society recognises that health workers are contributing to the common good by standing at the
frontlines of the battle against the COVID-19 outbreak, longstanding violations of legal provisions
with regard to their wages should be acknowledged and addressed. Notifications should be issued
so that wages are provided as per existing government norms, and wage discrimination against
workers in informal employment should be addressed. The current budgets of most municipal
hospitals and state hospitals are too small to provide the legal wages to all workers, which has been
covered up through outsourcing of services such as cleaning and housekeeping.
The central government has formalised the central role of ASHAs in containment and community
outreach, highlighting once again their role as an essential workforce of the state health system. Yet,
the government guideline does not provide an additional budgetary allocation while, of course, all
other tasks are to continue - ante-natal care, vaccination, etc. A paltry Rs 1,000 per month for April
and May is to be paid by states from unspent money. Their contribution in the month of March is
not even acknowledged and, without additional budgetary allocation, most State governments might
not even pay this inadequate incentive. The government pretence that ASHAs are not workers of the
health system amounts to discrimination against an exclusively female workforce that is paid a
fraction of the prevalent minimum wage.
Central and State governments should make the required budgetary allocations to ensure that
ASHAs and other health workers deployed to respond to the emergency situation are provided the
remuneration they deserve, and at least as per the law. Such allocations should be incorporated in
subsequent annual budgets.
As the crisis intensifies, health workers will be asked to provide extra-time on a regular basis. This
extra time needs to be regulated to allow enough time-off to rest and recover. Healthcare workers'
burnout aids the spread of the virus. Breaks and time-off need to be maintained. Extra hours should
also be remunerated as per the law.
It has also been reported that public and private sector hospitals are forcing their staff to contribute
to the government relief fund from their wages, in part of in entirety. Health workers should not be
asked to compulsorily or voluntarily forego their wages in full or partly.
With the exception of specialised doctors, wages in private hospitals and other health facilities in
the private sector are abysmally low. This led to the Supreme Court recommending a wage increase
across the board in the private health sector (2016). The recommendation has largely been un-
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implemented. In some states, such as in Delhi, the High Court directed the state government to
legislate towards the implementation of the Supreme Court recommendation. Yet, no such steps
have been taken. Considering that health workers in private facilities will also be involved in
responding to the COVID-19 epidemic, state governments should ensure compliance with the
Supreme Court recommendations relating to wages in private healthcare facilities.
Due to the financial crisis that preceded the COVID-19 pandemic many health workers such as
ambulance drivers, but also cleaning staff and ward attendants, had not received their payments for
months. The increased budgetary provision should prioritize payment of such arrears. As the
lockdown requires minimising non-essential activities and some workers have been asked to join
duty on alternate days, including for those working in hospital settings, special attention should be
given so that those working fewer hours because of the lockdown are paid their full salaries, even if
they are hired through manpower agencies, or on short-term contracts and other informal
employment conditions. For instance, safai karamcharis might find it difficult to travel to the
hospital they work in because of the shutdown of public transport. They should be considered on
duty for the full period of the lock-down. Finally, private sector hospitals are threatening to cut
wages in the month of April due to fewer patients and reduced “business” in that period. The
government should actively monitor that wages of health workers are paid. A health worker
helpline linked to both the Ministry of Labour and Ministry of Health should be available for
health-workers to notify non-payment of wages and arrears.
I) Adequate facilities across needs
Health workers working in high-risk areas, such as isolation wards, have to be provided the option
of adequate hostel accommodation so that they can avoid going home where there are old relatives
or young children whose health they are concerned about. They should not be asked to vacate the
hostel once their 14-days shift is over, as they risk to expose their families if they go back home.
Separate restrooms for medical personal in direct contact with COVID-19 patients should be
provided. Some states have taken steps to provide accommodation to doctors in hotels near the
hospitals where their work. There is no justification for the same benefits not being provided to
nurses and paramedics in direct contact with patients.
A large proportion of health workers are women who often face the double burden of housework
and care for their families as well as work outside the house. Adequate provisions should be made
to ease the burden of family care, including by providing options for crèche or childcare outside the
hospital setting. This is essential since regular childcare and schools are shut.
Soap and water should be made available in all facilities for workers and the public as a basic
hygiene measure. Hand sanitizers and detergent should be provided to all health workers on a
regular basis to facilitate personal hygiene.
Transport to the place of work, especially for those who do not have private transport, should be
provided, particularly if the lockdown is extended. There are reports of cleaning staff in cities such
as Delhi not able to join work due to the lockdown and decrease in public transport facilities. This
impacts the smooth functioning of hospitals, as well as creates hardship and stress for the workers
who are worried that their salaries will be cut for the days they are not able to attend work. ASHA
workers are facing similar issues as they have to travel from one house to an other.
Lack of nutritious food compromises immunity and puts health workers at risk of coronavirus.
Adequately nutritious food needs to be made available to health workers at the hospital, through the
public distribution system, or through other effective systems.
j) Stigma, social exclusion, violence and sexual harassment
We have seen during previous virus outbreaks that health workers are at risk of stigma and social
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exclusion. Even during the current COVID-19 epidemic there are reports of health workers being
asked to leave their rented accommodation. Other reports have surfaced of health workers being
attacked or harassed during tracing of potential COVID-19 cases or during their routine service
delivery. Particularly distressing are reports of healthcare staff who have become victims of
COVID-19 being refused burial or cremation services because of such stigma, when it is well
known that there is little danger of infection from dead bodies. The government should take
appropriate steps to ensure a safe workplace and work environment, including a strong media
campaign to counter stigma of all forms, and appropriate orders to outlaw stigma and
discrimination. A grievance redressal mechanism should be put in place, including internal
complaints committee in case of sexual harassment.
Health workers, including nurses, bringing lapses in treatment and protocols to the attention of the
public or speaking out about their working conditions are being gagged and harassed. Hospital
management and administrators may be stretched but unethical practices cannot be allowed to
persist and health workers’ role as whistle-blowers should be protected.
Health workers also face violence and harassment from the police while travelling to work, or
crossing inter-state barriers to travel from home to their workplace. The government should order
health facilities to provide letters on the appropriate official letterhead to all health workers, with
an order to the local police and administration to allow their travel, so that they are not harassed
by the police and other officials when travelling to work.
k) Filling of vacancies with a perspective of long-term hiring
Existing gaps in human resources vary between states but are generally substantial. According to
information collected through an RTI in 2017, in the facilities under the Delhi government, 14% of
the sanctioned posts of general duty medical officers (GDMO) were vacant (though another 4%
were filled by contractual staff), and 20% of staff nurse posts were vacant (though the large
majority were actually filled by contractual staff). According to reports, in Uttarakhand, 50% of
sanctioned posts for medical officers and 31% for staff nurses are vacant. These vacancies need to
be filled urgently, with a perspective of prioritising long-term hiring. The waiting list of the Union
Public Services Commission (UPSC) and the Staff Selection Commission (SSC) should be used as a
base to fill vacancies in health facilities under the central government. The waiting list of the
equivalent board or commission under each state should be used to fill vacancies in facilities under
the state governments. Kerala has undertaken this process successfully, using online interviews and
video conferencing. More recently, the Government of Tamil Nadu has appointed 530 doctors,
1,000 nurses, and 1,508 lab technicians through this method.
Considering the lockdown and closure of inter-state boarders, the situation might arise where
candidates on UPSC) or SSC lists are not in the state where the post is available. In such cases, a
temporary adjustment between sanctioned posts under the States and the Centre can be considered.
Considering the need for additional staff, those currently employed on contract should be allowed to
continue with their services. However, hiring on a short-term contractual basis or through
manpower agencies should not be seen as an adequate solution for increasing staffing under the
impression that the time saved in hiring provides a considerable advantage. Those employed on
short-term contracts and contracted through third party agencies are at risk of discrimination with
regard to access to personal protective equipment, leave and other safeguards. This increases the
risk of infection of this vulnerable workforce and weakens the risk management process in the
facility ― putting the larger public at risk.
The public expenditure on health as a percentage of GDP for 2017-18 was a mere 1.28%, while
WHO advises for at least 5% of GDP. Increased budgetary allocation for health will be required to
fill existing vacancies and should be incorporated into subsequent annual budgets.
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In summary, our demands are as follows:
SPECIFIC
1. The Government should provide updated guidelines regarding the rational use of PPE that
also cover non-COVID-19 facilities, facilitate the production and logistics of distribution,
increase PPE procurement orders to ensure adequate access to all health workers, and if
required, intervene in the market to ensure that PPEs are sent to the districts/regions where
they are urgently needed.
2. The government should ensure that guidelines regarding the use of PPE are strictly followed
in both public and private settings, and that there is no discrimination against workers on the
basis of hierarchy, employment status, or other reasons. A monitoring mechanism should be
put in place in order to enforce strict adherence to PPE guidelines in public and private
settings.
3. The government should ensure comprehensive health care free of cost to all health workers,
including outpatient, hospitalisation, and regular testing, with special attention to informal
health workers. Special provision of regular testing needs to be ensured for health workers
performing high risk tasks, even if asymptomatic.
4. The government life insurance scheme should cover all health workers including in private
settings and the estimate of health workers needs to be modified to reflect the real size of the
health workforce in order to avoid denial of compensation in the future.
5. Special paid leave in case of COVID-19-related sickness and quarantine should be provided,
including to workers on short-term contracts and employed through a third party. A special
compensation should also be announced for health workers who contract COVID-19 as an
occupational disease.
6. Health workers who are pregnant, lactating or have co-morbidities should not be put on duty
in the COVID-19 ward. They should be assigned appropriate tasks within their profession
that does not expose them to the risk of COVID-19.
7. Health workers' right to opt out of work when they are not provided with a safe working
environment and adequate protective equipment should be respected.
8. The government should facilitate appropriate training programmes and materials for the
diverse categories of health workers and for the different levels of risk depending on the role
of workers and the role of facilities.
9. Extra hours should be regulated and remunerated as per the law. Breaks and time-off need to
be maintained.
10. Adequate arrangements need to be provided to health workers in high-risk environments,
such as ICUs and isolation wards, including accommodation and separate restrooms.
11. The government should take appropriate steps to ensure a safe workplace and work
environment, protect health workers from harassment by the police and the community,
including a strong media campaign to counter stigma of all forms, and appropriate orders to
outlaw stigma and discrimination. A grievance redressal mechanism should be put in place,
including internal complaints committee in case of sexual harassment.
INSTITUTIONAL
12. Central and State governments should involve health worker unions in the process of
information-sharing, training, and workers’ safety. This will facilitate an effective outreach
to all concerned health workers. Managements should facilitate an active role for health
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workers' representatives in determining safety measures and safeguards of their health.
13. The infection control component of the government's quality accreditation programmes
must be implemented universally across states, including in the private sector, along with a
monitoring mechanism by the government. In case private facilities fail to follow the
government guidelines and resolve issues with regard to infection control and other
safeguard measures, the state government should consider requisitioning the errant private
facilities.
14. Management of health facilities should make adequate arrangements for health workers at
the facility, including but not limited to options for crèche or child care, transport to the
place of work, an official letter and an order to the local police and administration so that
health workers are not harassed by the police when travelling to work, regular provision of
soap and sanitizer, and adequately nutritious food at the hospital or through other effective
systems.
15. Health workers who are not able to work on a regular basis due to the lockdown or due to
precautionary measures should be considered on duty and paid their full wages. All
governments and private facilities should refrain from asking health workers to
compulsorily or voluntarily forego their wages in full or partly. A health worker helpline
linked to both the Ministry of Labour and Employment and the Ministry of Health and
Family Welfare should be available for health workers to notify non-payment of wages and
arrears.
16. State governments should ensure compliance with the Supreme Court recommendations
relating to the long overdue increase of wages in private healthcare facilities. Relevant
directions should be issued in this regard.
17. There should be a health worker helpline that is able to provide online or telephonic support
to health workers in both public and private sector, and protect health workers role as
whistle-blowers without putting their jobs at risk. This helpline should register complaints
and grievances and be linked to competent authorities who would be responsible for taking
timely action on these complaints.
18. The waiting list of the UPSC and the SSC should be used as a base to fill vacancies in health
facilities under the central government. The waiting list of the equivalent board or
commission under each state should be used to fill vacancies in facilities under the state
governments. Health workers hired on a short-term contractual basis are a vulnerable
workforce at increased risk of infection. This weakens the risk management process in the
facility and puts the larger public at risk.
19. Central and state governments should/must increase their budgetary allocations for health in
order to cover health workforce-related costs, such as filling up vacancies, regularization of
informal workers including scheme health workers, payment of wages as per the law and
payment of arrears. This increase should be incorporated into subsequent annual budgets.
This will be of long-term benefit for strengthening the public health system in India, and so
we can cope better when the next health crisis hits us.
10

The Spectator

Two weeks ago, I wrote about ‘the Swedish experiment’ in The Spectator.  As the world went into lockdown, Sweden opted for a different approach to tackling coronavirus: cities, schools and restaurants have remained open. This was judged by critics to be utterly foolish: it would allow the virus to spread much faster than elsewhere, we were told, leading to tens of thousands of deaths. Hospitals would become like warzones. As Sweden was two weeks behind the UK on the epidemic curve, most British experts said we’d pay the price for our approach when we were at the peak. Come back in two weeks, I was told. Let's see what you're saying then. So here I am.

I'm happy to say that those fears haven’t materialised. But the pressure on Sweden to change tack hasn’t gone away. We haven't u-turned. We’re careful, staying inside a lot more. But schools and shops remain open. Unlike some countries on the continent, no one is asking for ‘our papers’ when we move around in cities. The police don’t stop us and ask why we are spending so much time outdoors: authorities rather encourage it. No one is prying in shopping baskets to make sure you only buy essentials.
The country’s Public Health Agency and the ‘state epidemiologist’, Anders Tegnell, have kept their cool and still don’t recommend a lockdown. They are getting criticised by scientific modellers but the agency is sticking to its own model of how the virus is expected to develop and what pressure hospitals will be under. The government still heeds the agency’s advice; no party in the opposition argues for a lockdown. Rather, opinion polls show that Swedes remain strongly in favour of the country’s liberal approach to the pandemic.
So why isn’t Sweden changing tack in the fight against the pandemic? ‘The evil that is in the world always comes of ignorance’, wrote Albert Camus in The Plague – a book that eerily depicts the suffering of the human condition when a disease sweeps through society. And lately, scientists and observers have ventured that explanation publicly: perhaps Sweden’s refusal to fall into line is because Tegnell and his team are a bunch of philistines?
A group of 22 scientists made that charge in an op-ed last week in Dagens Nyheter, appealing to the government to rein in supposedly ignorant officials at the Public Health Agency. Last week, a piece in the Daily Telegraph ran with the same theme and expanded it to include much of the national population: Swedes have willingly been duped by ignorant authorities and a chief epidemiologist who has been seduced by his own sudden fame. Our faith in government is so big, and our bandwidth for dissent is so small, that we even scold criticism of the government as ‘shameful betrayal of the national effort’. A journalist from French television that I talked to on Sunday admitted, somewhat sheepishly, that ‘it’s almost as if we want Sweden to fail because then we would know it is you and not us that there is something wrong with’.
There is a simpler explanation: Sweden is sticking to its policy because, on the whole, it is balanced and effectual. So far, the actual development is generally following the government’s prediction. On Monday, 1,580 people had died and tested positive for Covid-19. The number of daily deaths has remained pretty stable at about 75 for a while but is now on a declining path. A lot more people will die in the next weeks and months but our death toll is far away from the pessimistic and alarmist predictions suggesting 80 to 90,000 people would die before the summer.
There are also encouraging signs that the growth of reported infections is also slowing down – a development that holds for both Stockholm (by far the worst affected region) and the rest of the country. The estimate from the Public Health Agency is that 100,000 people will show up at a hospital and test positive for Covid-19: the current headcount, just south of 14,800, suggests we are broadly in line with that estimate – if not below it.
Perhaps more important is the situation at our hospitals and their intensive care wards. The main ambition of suppression policies, after all, has been to avoid hospitals getting overwhelmed by patients they cannot treat because of shortages of staff, equipment and intensive care beds. Modellers in Sweden that have followed an Imperial College type approach have suggested demand will peak at 8,000 to 9,000 patients in intensive care per day. But actual numbers are telling a very different story. Yes, the situation is stressful, but – mercifully – the growth in intensive care patients has slowed down remarkably and the number of patients currently in intensive care has flatlined.
We now have about 530 patients in intensive care in the country: our hospital capacity is twice as high at 1,100. Stockholm now averages about 220 critical care patients per day and its hospitals, far from being overwhelmed, have capacity for another 70. Stockholm also reports that it has several hundred inpatient care beds unoccupied and that people shouldn’t hesitate to seek hospital care if they feel sick. A new field ward has been set up in Stockholm for intensive and inpatient care and some predicted it would start getting patients two weeks ago. It hasn’t received any patients yet.
Sweden hasn’t declared 'victory' – far from it. It’s still early days in this pandemic and no one really knows yet how the virus will spread once restrictions are lifted and what excess mortality it will have caused when it’s all over. Sweden doesn’t know the size of its ‘iceberg’ – how many people that have had the virus with only mild or no symptoms. It will remain unclear for at least another couple of weeks if parts of Sweden (especially Stockholm) has developed some degree of herd immunity. 
A recent test at Karolinska suggested that 11 per cent of people in Stockholm had developed antibodies against the virus. Professor Jan Albert, who has led these tests, says the rate is most likely higher – perhaps substantially higher. So far they have only tested a small sample of blood donors and they can only donate if they are healthy and free of symptoms. Albert thinks the actual situation isn’t far away from the ballpark suggested by professor Tom Britton in a study that was released this weekend: that between 25 and 40 per cent of the Stockholm population have had the virus and that the region will reach herd immunity in late May. The Public Health Agency seems to be thinking along the same lines: by 1 May, it predicts in a brand new study, 30 per cent of the population in Stockholm will have had the virus.
These results are hopeful, even if they are still informed estimates and not observed reality. Nor will they change Swedish policy anytime soon. In fact, all the uncertainties around the future of this pandemic are part of the motivation for Sweden opting for a liberal approach. We have to plan for strong social distancing measures to remain in place for a long time and they won’t work if they are harder than necessary.
Countries like Austria and Denmark are now beginning to ease their lockdown restrictions but the virus is still spreading in their countries, albeit at a slower rate than earlier. Once more of the restrictions have been lifted, they may soon have to be imposed again to control new outbreaks of the virus. No country in Europe has yet figured out how a policy of test, track and trace could be organized on a large scale. We don’t know when a vaccine will be ready. For the foreseeable future, the backbone of every country’s defence against the virus will have to be based on strong social distancing. Sweden’s authorities proposed a liberal approach based on individual responsibility because it can be tolerated for longer and it has the effect of ‘flattening the curve’.
There is also a broader case for it. Lockdown policies harm basic civil liberties: in Sweden these liberties are, with some exceptions, intact. Lockdown policies have huge consequences on public health. And they are profoundly damaging to the economy. Sweden is no exception: our economy has been falling like a stone in the past month. In the city where I live, Uppsala, bankruptcy notices are now put up on many shop windows and I hear every day about friends and acquaintances that have lost their jobs or their small firms. National production has also slipped because global trade has closed. Big industrial stalwarts like ABB and Sandvik are still producing but can’t ship their products to other countries. Carmakers like Volvo and Scania decided to close their factories at an early point in March because they couldn’t get parts and components from other countries.
So everyone was already set up for gloomy reading about the economic outlook when the government unveiled its new budget last week. Still, the experience was grim. In the main scenario, our national output will decline by 4 per cent this year, taking unemployment up to 9 per cent and the fiscal deficit to 3.8 per cent of the gross domestic product.
The only silver lining is that it could have been worse. We are pretty far away from the levels of economic decline predicted for most lockdown countries. In fact, the Swedish economic situation looks sensationally positive when compared to the ghastly reports and scenarios elsewhere. Cash turnover indicators, for instance, suggest that personal consumption in Denmark and Finland has dropped by 66 and 70 per cent respectively – compared to less than 30 per cent in Sweden. Unemployment benefit claims in Norway has shot through the roof and grown four times as fast as in Sweden. Fiscal deficits in the UK and the US are likely to be in the region of 12 to 15 per cent. Last week’s economic scenario from the OBR suggested that Britain’s GDP could drop by almost 13 per cent this year.
So yes: the economy has to be factored into a balanced pandemic response if it is going to last for longer than a few weeks more. No country can sustain suppression policies if they have catastrophic consequences for the economy. Many countries can borrow cash now to pay people that aren’t working and help businesses that are on the verge of bankruptcy. But that isn’t an unlimited option. Debt accumulated now will have to be repaid later. We can hope for a sharp economic recovery but chances are that it will be slow and that it will take years to rebuild national production. And we already know what that means: unemployment will remain high, people will be poorer and there will be less spending on benefits, welfare services and core state functions like the police. Sweden won’t be spared, but our economy will not be as ravaged as elsewhere.
So Sweden isn’t edging closer to a lockdown. Nor is team Tegnell panicking and fighting for its reputation. The vast majority of people think Sweden broadly opted for a balanced and effectual policy and current trends support that view. Everyone is upset about carelessness in nursing homes – that a very high share of our death toll is elderly nursing home residents – and that emergency plans were so poor and medical contingency stocks so small. People will be held to account. Some heads will roll. My guess is that it won’t be Tegnell’s.      

Tuesday, 21 April 2020

जीन चिकित्सा के नए औजार

जीन चिकित्सा के  नए औजार

              यदि आप बैक्टीरिया.संक्रमण के कारण ज्वर ग्रस्त हैं तो डॉक्टर उपयुक्त एंटिबायोटिक द्वारा आपका उपचार करेगा और एक सप्ताह की अवधि में आप ठीक हो जाऐंगे। ऐसा ही न्यूमोनिया जैसे अधिक गंभीर रोगों में भी होता है। ये उपार्जित रोग हैं। पर हीमोफीलिया, पुटीय तंतुशोध (सिस्टिक फाइब्रोसिस), सिकल सेल अरक्तता और कुछ प्रकार के कैंसर जैसे जन्मजात रोगों का क्या करें ? ये हमारे जीनों में दोष के कारण होते हैं। ये रोग इसलिए प्रकट होते हैं क्योंकि या तो कोई आवश्यक प्रोटीन उत्पन्न नहीं हो पाता या कोई संसाधित प्रोटीन उत्पन्न हो जाता है या फिर कुछ कोशिकीय नियंत्रण प्रकार्य नहीं हो पाते हैं। डॉक्टर इनमें से अधिकांश रोगों को ठीक नहीं कर पाते हैं, वे केवल उनका प्रबंधन करते हैं। तथापि 1970 के दशक के आरंभ में हुए जैव प्रौद्योगिकीय
प्रवर्तन के बाद से, अन्वेषक इन रोगों के मूल.दोषी जीनों पर प्रहार करने की तकनीकें विकसित कर रहे हैं। यह चिकित्सा प्रद्धति, जिसे उपयुक्त रूप से ही ‘‘जीन चिकित्सा’’ कहा जाता है  रोग के लिए प्रकार्यात्मक उपचार प्रदान करने के लिए दोषी जीन को हटाने, या उसकी मरम्मत करने या उसके प्रकार्य को सामान्य जीन से संपूरित
करने के प्रयास करती है। 1970 के दशक के शुरुआती वर्षों में एक निष्क्रिय वायरस या प्लाज़मिड में
सामान्य जीन डाल कर उपयोग में लाया जाता था। जब ऐसे वाहक को कोशिका में समाविष्ट किया जाता है तो अभिनव जीन अपने आपको विकृत जीन की क्षतिपूर्ति के लिए कोशिका के जीनोम में समेकित कर देती है। यद्यपि अनेक चिकित्सकीय परीक्षण किए जा चुके हैं और कुछ में सफलताएं भी मिली हैं, वाहक.आधारित जीन
थीरेपी में अनेक दोष हैं। इस प्रणाली में एक नई जीन को समाविष्ट किया जा सकता है किंतु विकृत जीन को सुधारा या शांत नहीं किया जा सकता। इससे भी अधिक महत्वपूर्ण बात यह है कि नई जीन परपोषी जीनोम में यादृच्छिकतः ही समाविष्ट की जा सकती है न कि विशिष्ट लक्ष्यित स्थल पर। इसके अन्य जीनों पर अनियंत्रित उत्प्रेरक या निरोधी प्रभाव हो सकते हैं या फिर यह भी हो सकता है कि नई स्थिति में यह अभिनव जीन अपेक्षा के अनुसार कार्य न करे। इसलिए कुछ और चाहिए था जो अधिक परिशु़द्ध और विश्वसनीय हो।
         गत दो दशकों में अन्वेषकों ने, विकृत जीनों की परिशुद्ध अभियांत्रिकी के लिए - उन्हें बाहर   निकालने, संशोधित करने अथवा किसी विशिष्ट स्थल पर नवीन जीन सन्निविष्ट करने के लिए - तीन विशिष्ट औजार विकसित किए हैं। सभी तीनों पद्धतियों में कुछ सामान्य यांत्रिक लक्षण विद्यमान हैं। प्रत्येक के दो प्रभाव क्षेत्र हैं - एक जीनोम में डी एन ए अनुक्रम के उन स्थलों को पकड़ना जहां परिवर्तन किए जाने हैं और दूसरा डी एन ए को
उस लक्ष्यित अनुक्रम में परिशुद्धता से काटना ताकि द्वि.तंतु भंजन हो सके जो कि जीन संशोधन के आगे के चरणों के लिए एक पूर्वापेक्षा है। अपनी परिशुद्धता के कारण इन औजारों को ‘‘आण्विक कैंची‘‘ नाम से अभिहित किया जाता है। इनके नामें की प्रसिद्धि इनके परिवर्णी शर्ब्दों .  ZFNs, TALENs तथा  CRISPRs  से है।
ZFNs (जिंक फिंगर न्यूक्लिएजे़ज)--
               1990 के दशक में  विकसिर्त ZFNs लक्ष्यित जीनोम संशोधन के सबसे पहले अभियांत्रित औजार हैं। इस डी एन ए बंधनकारी डोमेन में एक प्रोटीन.संरचना होती है जिसमें प्रत्येक प्रोटीन का जिंक आयनों द्वारा स्थायीकृत, उंगली की तरह बाहर निकला हुआ उद्वर्तन होता है (इसी कारण इनको यह नाम दिया गया है)। प्रत्येक उद्वर्तन, डी एन ए में तीन न्यूक्लिओटाइड आधारों के अनुक्रम से बंधित हो सकता है। जिंक फिंगर प्रोटीन (ZFP) की बंधनकारी विशिष्टता को अमीनो अम्ल अनुक्रम को प्रभावित करके बदला जा सकता है। डी एन ए की किसी लम्बाई की बंधनकारी विशिष्टता में सुधार के लिए कई  ZFPs  एक साथ टांके जा सकते हैं। आम तौर पर तीन से छ ZFPs का एक मोटिफ, लक्ष्यित डी एन ए में, न्यूक्लिओटाइड आधारों के एक विशिष्ट अनुक्रम को बंधित करने के लिए अभियांत्रिक किया जाता है।
डी एन ए विभाजक क्षेत्र, FoKI नामक एक   निर्बंधन एंज़ाइम है जिसमें अविशिष्टीकृत रूप से डी एन ए से बंधित होकर उसे विभाजित करने की क्षमता होती है। FoKI एक मंदकर है। यह तभी प्रभावी होता है जब दोनों भाग उपस्थित हों। इसलिए, र्दो ZFN मोटिफों में प्रत्येक जिसके बंधनकारी गुण लक्ष्पित डी एन ए विशिष्ट हों, FoKI  एंज़ाइम से युग्मित होकर एक जिंक फिंगर न्यूक्लिएज निर्मित करता है। ZFN  की उत्पत्ति के संबंध में एक रोचक कहानी है।) जब यह तंत्र किसी कोशिका में सन्निविष्ट किया जाता है तो दोनों बंधनकारी एकक लक्ष्यित स्थल के पार्श्वों में आ जाते हैं और FoKI  एंज़ाइम दोहरे DNA  तंतुओं के पास आते जाते हैं और इसे काट कर दोहरे भंजित तंतु उत्पन्न करते हैं।
TALENs (प्रंतिलिपि सक्रियक - वत् प्रभावक न्यूक्लिएजेज) ।TALENs के  DNA  बंधनकारी क्षेत्र प्रतिलिपि सक्रियक.वत् प्रभावक TALEN  प्रोटीनों से बने होते हैं जो जैंथोमोनास बैक्टीरिया द्वारा स्रावित किए जाते हैं। इन प्रोटीनों का प्रेक्षण पहली बार मार्टिन लूथर किंग विश्वविद्यालय, जर्मनी में जीवविज्ञान संस्थान के यूबोनैस द्वारा 2009 में किया गया था। (जैंथोमोनास बैक्टीरिया पादप रोगकारी हैं और वे TALEs  का उपयोग अपने परपोषियों में विशिष्ट जीनों को सक्रिय बनाने के लिए करते हैं ताकि संदूषण के प्रति परपोषी की संवेदनशीलता को अधिकतम किया जा सके। TALE  प्रोटीन में आगे पीछे जुड़े अमीनो अम्ल पुनरावर्त क्षेत्रों की विभिन्न संख्याएं विद्यमान होती हैं और प्रत्येक क्षेत्र, डी एन ए  के  एक विशिष्ट न्यूक्लिओटाइड आधार से बंधित होता है। बंध के लिए उत्तरदाई अमीनो अम्ल को परिवर्तित करके प्रोटीन के बंधनकारी गुण में बदलाव लाया जा सकता है ताकि वह किसी भी डी एन ए अनुक्रम के लिए उपयुक्त रहे। ZFNs  की तरह ही TALE  प्रोटीनों का एक युग्म भी डी एन ए.विभाजक एण्डोन्यूक्लिएज FoKI  मंदक के साथ जुड़ कर एक TALEN  एकक निर्मित करता है जो जीन संशोधन का एक प्रभावी औजार होता है। क्योंकि प्रत्येक TALEN
17 या अधिक न्यूक्लिओटाइड आधारों से बंध बना सकता है, इसके द्वार्रा ZFNs  की तुलना में अधिक विशिष्टता प्राप्त करना आसान होता है।
CRISPRs  (क्लस्टर्ड रेम्युलरली इन्टरस्पेस्ड शॉर्ट पैलिंड्रोमिक रिपीट्स)
        1980 के दशक के आखिरी वर्षों में, बैक्टीरिया ई. कोली के जीनोम का अनुक्रमण करते हुए जापानी वैज्ञानिक योशिजुमिल्शिने और उनके सहयोगियों ने एक असाधारण डी एन ए अनुक्रम देखा जिसमें पांच सर्वसम किंतु पैलिंड्रोमिक डी एन ए पुनरावर्त्त अनुक्रम थे जिनमें से प्रत्येक में 29 न्यूक्लिओटाइड आधार थे। ये पुनरावर्त्त अनुक्रम, देखने में यादृच्छिक 32 आधार अनुक्रमों द्वारा, परस्पर पृथक्कृत थे, जिन्हें ‘‘स्पेसर्स‘‘ कहा गया।
पुनरावर्त्त अनुक्रमों के विपरीत प्रत्येक स्पेसर का अपना एक अनन्य आधार अनुक्रम था। बाद में अन्य वैज्ञानिकों ने अत्यंत विविध सूक्ष्मजीवों में इसी प्रकार के अनुक्रम खोजे। तथापि इन मध्यवर्ती अनुक्रमों का जीव वैज्ञानिक महत्व स्पष्ट नहीं था और इन्हें ‘‘क्लस्टर्ड रेग्युलरली इन्टरस्पेस्ड शॉर्ट पैलिनड्रॉमिक रिपीट्स‘‘ अथवा CRISPRs कह कर पुकारा गया। यह भी प्रेक्षित किया गया कि CRISPR  अनुक्रम के साथ जीनों का एक संकलन संलग्नित था जिसे CRISPR  जीन अथवा Cas  जीन नाम दिया गया। ये जीन उस डी एन ए न्यूक्लिएज़ को कोडित करते हैं जो डी एन ए तंतु को काट सकता है। वैज्ञानिकों के अन्य दलों ने देखा कि स्पेसर डी एन ए वायरस जीनोम के खंडों के सदृश्य है। जानकारी के इन अलगअलग टुकड़ों को जोड़कर वैज्ञानिकों ने सुझाया कि बैक्टीरिया CRISPR-Cas तंत्र का उपयोग सभवतः आक्रमणकारी वायरसों  और प्लास्मिडों से अपनी रक्षा के लिए करते हैं। जब कोई वायरस हमला करता है तो बैक्टीरिया वायरस डी एन ए का एक टुकड़ा CRISPR  क्षेत्र में स्पेसर के रूप में सन्निविष्ट कर देता है। अगली बार जब बैक्टीरिया का सामना उस वायरस से होता है तो वे स्पेसर में मौजूद डी एन ए का उपयोग करके एक RNA  निर्मित करते है जो वायरस के डी एन ए में मौजूद उस जैसे अनुक्रम को पहचान कर उससे बंधित हो जाता है। एक Cas  प्रोटीन RNA  के साथ जुड़ कर वायरस के डी एन ए को काट देता है और इसके प्रतिकृतिकरण को रोक देता है। 2012 में, कैलिफोर्निया विश्वविद्यालय, बर्कले की जेनिफर दौडना और उनके सहकर्मियों ने (अनेक Cas  एन्जाइम में से एक) Cas9  नामक विशिष्ट एन्जाइम के साथ युग्मित एक एकल RNA  अभिकल्पित किया जो परखनलियों में मेल खाते डी एन ए अनुक्रमों की परतें उतार सकता था। अगले वर्ष MIT  के फेंक झांग तथा हार्वर्ड मेडिकल कॉलेज  के जॉर्ज चर्च ने स्वतंत्र रूप से रिपोर्ट किया कि CRISPR/Cas9 का उपयोग मानव सहित सभी प्रकार की जंतु कोशिका में जीन संशोधन के लिए
किया जा सकता है। व्यवहार में  किसी जीन में सुधार हेतु CRISPR/Cas9 प्रणाली का उपयोग करने के लिए जीन में विद्यमान विशिष्ट डी एन ए अनुक्रम से मेल खाते RNA  को संश्लेषित किया जाता है और इसे Cas 9 एंज़ाइम के साथ मिला दिया जाता है। जब यह संरचना परपोषी कोशिका में सन्निहित की जाती है तो RNA  एंज़ाइम को लक्ष्यित अनुक्रम तक ले जाता है जहां Cas 9  एंज़ाइम डी एन ए के दोहरे तंतु में विभाजन करता है। और क्योंकि लक्ष्यित अनुक्रम कोई भी हो विभाजक एंज़ाइम वही इस्तेमाल किया जाता है, यह संभव है कि केवल
Cas 9  और संगत RNA  गाइडों का उपयोग करके परपोषी कोशिका में बहुजीनों को चुनौती दी जा सके।
        जीन संपादन में आगे के चरण 
डी एन ए को होने वाली कोई भी क्षति कोशिका में प्राकृतिक मरम्मत के काम को उद्दीपित कर देती है। लक्ष्यित स्थल पर दोहरे तंतु के भंजन की मरम्मत ‘नॉन होमोजीनस एण्ड जोयनिंग  NHEJ  नाम के प्रक्रम से होती है जो टूटे शिरों को जोड़ देता है। किंतु यह विधि त्रृटिपूर्ण होती है जिससे इसमें कुछ आधार  जुड़ या घट जाते हैं और जीन दुष्क्रियात्मक हो जाता है। विकल्प के रूप में जीन पर प्रहार करने के बजाय एक अन्य प्रक्रम जिसे समांग
पुनर्योजन निदर्शित (HD ) मरम्मत कहते हैं जीन मरम्मत के लिए उद्दीपित किया जा सकता है। यदि एक ‘दाता‘
डी एन ए अनुक्रम जो सही जीन अनुक्रम निरूपित करता है प्रस्तुत किया जाए तो कोशिका इसका उपयोग मूल जीन को सुधारने के लिए सांचे के रूप में कर सकती है। दूसरी ओर यदि कोई एक दम नया जीन अनुक्रम प्रस्तुत किया जाता है तो परपोषी, जीनेाम में पूर्वनिर्धारित स्थिति पर एक नया जीन निविष्ठित हो जाता है। सामान्यतः निष्क्रिय किए गए वायरसों और प्लास्मिडों का उपयोग वाहकों के रूप में जीन.संपादन औजारों को कोशिका में पहुंचाने के लिए किया जाता है। यहां तक कि कुछ अन्वेषक विद्युत कण संचलन - निम्न वोल्टता विद्युत विसर्जन - का उपयोग कोशिका झिल्ली में औजार प्रविष्ट कराने के लिए छिद्र बनाने के लिए करते हैंर्। ZFNs  एवं
TALENs  पिछले कुछ वर्षों से प्रयोग में हैं और इनकी दक्षता, सुरक्षा, संभावित साइड प्रभावों आदि की जांच के लिए व्यापक परीक्षण, सवंर्धित मानव कोशिकाओं और विभिन्न जंतु मॉडलों पर किए जाते रहे हैं। इनका अनुसरण करते हुए अनेक चिकित्सा.पूर्व परीक्षण रक्त संबंधी (जैसे सिकेल सेल अरक्तता) एवं प्रतिरक्षा तंत्र संबंधी (HIV / AIDS)रोगों के उपचार के लिए किए जा रहे हैं। उदाहरण के लिए कैलिफोर्निया विश्वविद्यालय, बर्कले के अन्वेषकों ने सिकेल सेल अरक्तता ग्रस्त रोगियों की संबंधित अस्थि.मज्जा से स्टेम.कोशिकाएं लेकर उर्न्हें ZFNs  से उपचारित किया और उत्परिवर्तन को सुधारने में सफल हुए। उन्होंने मूषक.मॉडलों में यह भी प्रदर्शित किया कि संशोधित अस्थि.मज्जा स्टेम कोशिकाओं में सफल प्रतिकृतिकरण तथा सामान्य लाल रक्त कोशिकाओं  को उत्पन्न करने की क्षमता होती है। अभी हाल ही में यू. के. के चिकित्सकों ने एक 1 वर्ष आयु की
लड़की के श्वेतरक्तता रोग (एक प्रकार के रक्त कैंसर) के उपशमन में सफलता प्राप्त की, इसके लिए TALENs  द्वारा संपादित प्रतिरक्षा कोशिकाओं से उसे उपचारित किया ताकि कैंसर कोशिकाओं को पहचान कर नष्ट किया जा सके।
       CRISPR/Cas9 प्रणाली केवल 2013 से ही अन्वेषकों को उपलब्ध रही है। तथापि  ZENs  और
TALENs  की तुलना में यह औजार अधिक आसानी से अभियंत्रित किए जा सकने और उपयोग में लाए जा सकने के कारण इसका उपयोग तेजी से बढ़ रहा है। CRISPR/Cas9 का अन्य लाभ यह है कि इसका उपयोग एक से अधिक जीनों को लक्ष्यित करने के लिए किया जा सकता है जो उन रोगों के उपचार में बहुत लाभकारी है जो अनेक जीनों में उत्परिवर्तन के कारण होती हैं। MIT  के अन्वेषकों ने CRISPR/Cas9 औजार का उपयोग मूषक मॉडल में FAH  जीन (जो एंज़ाइम फ्यूमैराइलएसिटो एसिटेट हाइड्रोलेज को कोडित करता है) में उत्परिवर्तन को संशोधित करने के लिए किया। मानवों में  इस उत्परिवर्तन के परिणाम स्वरूप टायरोसिनेमिया नामक रोग हो जाता है जिसमें अतिरिक्त टायरोसिन - एक अमीनो अम्ल - शरीर में संचयित हो जाता है जिससे यकृत काम करना बंद कर देता है और मृत्यु तक हो जाती है। एडिटास मैडिसिन, जो कैम्ब्रिज मैसाचुसेट्स की जैव प्रौद्योगिकीय कंपनी है, 2017 तक उत्परिवर्तन जीन द्वारा उत्पन्न किए जाने वाले रेटिना के एक दुर्लभ रोग
का उपचार CRISPR/Cas9 के उपयोग द्वारा कर पाने के प्रति आशावान है। अधिकांश मामलों में, रक्त कोशिकाओं से उभरने वाले रोगों के उपचार की रणनीति है: रक्तकोशिकाओं की पूर्ववर्ती जिन्हें हेमेटोपोइटिक स्टेम कोशिका कहा जाता है, रोगी की अस्थि.मज्जा से निकालते हैं, उनका उपचार चुने गए जीन.संपादन औजार से प्रहार करके संशोधित करके नया जीन सन्निविष्ट करके करते हैं, संवर्ध में उनकी वृद्धि  करते हैं, सफल संपादन सुनिश्चित करने के लिए जीनोम अनुक्रमण के माध्यम से उनकी जांच करते हैं और फिर वापस उन्हें रोगी में (बहजीवै) इंजैक्शन द्वारा पहंुचा देते हैं। नियम यह है कि कोशिकाओं की पर्याप्त संख्या में संशोधन से रोगी को दीर्घकालिक रोगहर उपचार प्राप्त हो सकता है। यकृत जैसे अंगों में जहां से कोशिकाओं को निकाला ओर वापस पहंुचाया नहीं जा सकता जीन संपादन औजार युक्त वाहक पर्याप्त संख्या में सीधे उस अंग तक इंजेक्शन द्वारा पहुँचा दिए जाते हैं (अंतः जीवै) CRISPR/Cas9 एक कदम और आगे बढ़ रहा है - जर्म.लाइन संपादन अथवा भु्रण संपादन के माध्यम से जन्म से भी पहले जीनीय दोषों को दूर करना। उदाहरण के लिए एक चीनी अन्वेषक दल ने भ्रूण की एक.कोशिकीय अवस्था में CRISPR/Cas9 संरचना को इंजेक्शन द्वारा प्रविष्ट कराके दो जीनों का पुनर्लेखन किया और इस प्रकार जीनीय रूप से परिवर्तित वानर निर्मित किए। एक अन्य विकास क्रम में रिकंबिनेटिक्स नाम की कंपनी ने CRISPR/Cas9 प्रोद्योगिकी का उपयोग करके वृषभों के वीर्य जीनोम को संपादित किया और सींग विहीन मवेशी विकसित किए। इससे दूसरे जानवर और फार्म के कर्मचारी घावों से बच जाएंगे और पशुकल्याण होगा।
            अप्रैल 2015 में एक अन्य चीनी दल ने बीटा थैलेसीमिया नामक आनुवंशिक रुधिर रोग जो हीमोग्लोबिन का उत्पादन कम कर देता है, के लिए उत्तरदाई उत्परिवर्तित बीटा.ग्लोबिन जीन को शरण देने वाले मानव भ्रूण के संपादन प्रयासों की रिपोर्ट प्रस्तुत की। अंतः जीन संपादन अब विज्ञान कथा नहीं रह गई है यह एक वास्तविकता बनने जा रही है।
एम एस एस मूर्ति --ड्रीम  2047, फरवरी 2017, खंड 19 अंक 5
(अनुवादकः रामशरण दास)

Covid 19 Bulletin 17 April 2020 (H)

Covid 19 Bulletin 18 April 2020 (H)

CSIRसीएसआईआर की एक और प्रयोगशाला में कोरोना वायरस की जीनोम सीक्वेंसिंग

कोशकीय एवं आणविक जीवविज्ञान केंद्र (सीसीएमबी) और जीनोमिक एवं समेकित जीवविज्ञान संस्थान (आईजीआईबी) के बाद वैज्ञानिक तथा औद्योगिक अनुसंधान परिषद (सीएसआईआर) की एक और प्रयोगशाला में नये कोरोना वायरस के संपूर्ण जीनोम अनुक्रमण (Genome Sequencing) का कार्य शुरू किया जा रहा है। चंडीगढ़ स्थित सीएसआईआर-सूक्ष्मजीव प्रौद्योगिकी संस्थान (इम्टेक) ने भी कोविड-19 की चुनौती से निपटने के लिए महत्वपूर्ण पहल करते नये कोरोना वायरस का संपूर्ण जीनोम अनुक्रमण शुरू कर दिया है।
इम्टेक के निदेशक डॉ संजीव खोसला ने कहा है कि “इस अनुक्रमण से प्राप्त जीनोमिक संसाधन कोविड-19 के लिए जरूरी निदान और दवाओं के लक्ष्यों की पहचान करने में कारगर हो सकते हैं। जीनोम अनुक्रमण के नमूनों को अंतरराष्ट्रीय मान्यता प्राप्त संग्रह में जमा किया जाएगा।” दूसरे सूक्ष्मजीवों की तुलना में वायरस के रूपांतरित होने की दर अधिक होती है, और उनकी आनुवंशिक सामग्री तेजी से बदलती रहती है, क्योंकि वायरस संख्या तेजी से बढ़ती रहती है। संपूर्ण जीनोम अनुक्रम की जानकारी होने से शोधकर्ता वायरस की उत्पत्ति, भारत में मौजूद उसके रूपों और हमारे देश में इसके फैलने बारे में जानकारी प्राप्त कर सकेंगे।

“इस अनुक्रमण से प्राप्त जीनोमिक संसाधन कोविड-19 के लिए जरूरी निदान और दवाओं के लक्ष्यों की पहचान करने में कारगर हो सकते हैं। जीनोम अनुक्रमण के नमूनों को अंतरराष्ट्रीय मान्यता प्राप्त संग्रह में जमा किया जाएगा।”
संपूर्ण जीनोम अनुक्रमण किसी जीव के जीनोम के पूर्ण डीएनए अनुक्रम को निर्धारित करने के लिए उपयोग की जाने वाली विधि है। सीएसआईआर-इम्टेक को सूक्ष्मजीव और जीनोमिक अनुसंधान में विशेषज्ञता के लिए जाना जाता है। यह संस्थान नैदानिक नमूनों से पृथक किए गए SARS-Cov-2 आरएनए जीनोम का अनुक्रमण करेगा। वर्ष 1984 में स्थापित सीएसआईआर-इम्टेक सूक्ष्मजीव विज्ञान में एक प्रमुख राष्ट्रीय स्तरीय उत्कृष्टता केंद्र है।
डॉ खोसला ने कहा, “हमने नमूनों का नैदानिक परीक्षण शुरू कर दिया है, और अब वायरल उपभेदों को अनुक्रमित करने के लिए इस मिशन को शुरू करते हुए हम इस वायरस की प्रकृति को समझने के लिए बेहतर रूप से सुसज्जित होंगे, जिसके कारण कोविड-19 वैश्विक महामारी फैल रही है।” यह संस्थान भारत में SARS-Cov-2 के उपभेदों में रासायनिक बदलावों का अध्ययन करने के लिए वास्तविक समय में पोर्टेबल और प्रत्यक्ष जीनोम अनुक्रमण में अपने अनुभव का उपयोग करेगा।
इंडिया साइंस वायर

CHITRA GENELAMP-N MAKES CONFIRMATORY TESTS RESULTS OF COVID-19 POSSIBLE IN 2 HOURS

CHITRA GENELAMP-N MAKES CONFIRMATORY TESTS RESULTS OF COVID-19 POSSIBLE IN 2 HOURS


Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, an institute of national importance of the Department of Science and Technology (DST), has developed a diagnostic test kit that can confirm COVID-19 in 2 hours at low cost. The confirmatory diagnostic test, which detects the N Gene of SARSCOV-2 using reverse transcriptase loop-mediated amplification of viral nucleic acid (RT-LAMP), will be one of the world’s first few, if not the first of its kinds, in the world. The test kit, funded by the DST called Chitra GeneLAMP-N, is highly specific for SARS-CoV-2 N-gene and can detect two regions of the gene, which will ensure that the test does not fail even if one region of the viral gene undergoes mutation during its current spread. The tests performed at NIV Alappuzha (authorized by ICMR) show that Chitra GeneLAMP-N has 100% accuracy and match with test results using RT-PCR. This has been intimated to ICMR, the authority to approve it for COVID-19 testing in India, following which license needs to be obtained from CDSCO for manufacturing. Current PCR kits in India enable detection of E gene for screening and RdRp gene for confirmation. Chitra GeneLAMP-N gene testing will allow confirmation in one test without the need for a screening test and at much lower costs. The detection time is 10 minutes and the sample-to-result time (from RNA extraction in swab to RT-LAMP detection time) will be less than 2 hours. A total of 30 samples can be tested in a single batch in a single machine allowing a large number of samples to be tested each day. “Development of a novel, inexpensive, rapid confirmatory for the diagnosis of COVID-19 by Sree Chitra in record time is a compelling example of how a creative team of clinicians and scientists working together seamlessly can leverage knowledge and infrastructure to make relevant breakthroughs. Establishment of a Technology Research Centre at SCTIMST and four other DST institutions has brought rich dividends by conversion of basic research into important technologies,” said Prof Ashutosh Sharma, Secretary, DST. The testing facility can be easily set up even in the laboratories of district hospitals with limited facilities and trained laboratory technicians. The results can be read from the machine from   the change in fluorescence. The cost with the new device for LAMP testing and the test kit for 2 regions of N gene (including RNA extraction) will be less than Rs 1000 per test for the laboratory. Sree Chitra has also additionally developed the specific RNA extraction kits along with GeneLAMP-N test kits and testing devices. The technology was transferred for manufacture to M/S Agappe Diagnostics Ltd, Ernakulam, a leading company in in-vitro diagnostics with national and international operations. Dr. Anoop Thekkuveettil, a senior scientist of the Biomedical Technology Wing of the Institute and Scientist-in-charge of the division of molecular medicine under the Department of Applied Biology and his team developed the kit in the last 3 weeks. For more details, please contact: Ms. Swapna Vamadevan, PRO, SCTIMST, Mob: 9656815943, Email: pro@sctimst.ac.in Website link: https://dst.gov.in/chitra-genelamp-n-makes-confirmatory-tests-results-covid-19-possible-2-hours


चिकित्सा पद्धति का विकास

चिकित्सा पद्धति का विकास
    मानव के होमोसेपियंस रूप में विकास होने पर उसकी बुद्धि के दौरान होने वाले संघर्षों का सामना वह अब शारीरिक शक्तियों के साथ-साथ बुद्धि से भी करने लगा।          समय के साथ मानव झुंड बनाकर या समूह में रहने लगा, जिससे 'हम' की भावना का विकास हुआ। इसके कारण उस समूह के सदस्यों की सुरक्षा सभी की जिम्मेदारी बन गई । इस सुरक्षा में जंगली जानवरों के हमले से लेकर बीमारिया रोगों का उपचार तक शामिल थे।
     समय के साथ प्रयोगों संयोगों एवं अनुभवों  के आधार पर मनुष्य का ज्ञान संग्रहित होता गया एवं कालांतर में यह एक पीढ़ी से दूसरी पीढ़ी में स्थानांतरित होता गया। इस प्रकार नई पीढ़ी अपने पूर्वजों से प्राप्त ज्ञान में अपने अनुभवों से प्राप्त ज्ञान जोड़ते गई एवं इस क्षेत्र का विशेष क्षेत्र के रूप विकास हुआ । श्रम विभाजन एवं वर्ण व्यवस्था के विकसित होने के साथ ही उपचार करना वैध का काम माना जाने लगा । इसके लिए इस ज्ञान को लिखित रूप में भी सहेज कर रखा जाने लगा । इस विषय अर्थात चिकित्सा शल्य क्रिया  का विकास इन उदाहरणों से स्पष्ट समझा जा सकता है:-
1.सर्वप्रथम मनुष्य या मानव ने बीमार होने पर जंगली जड़ी-बूटियों के सेवन से उपचार करना सीखा ।
2.किसी प्रकार की चोट लगने पर इसे दबाकर या बांधकर घाव से खून बहना बंद करना एक सामान्य बात हो गई जो आज भी किया जाता है ।
3.किसी नुकीली वस्तु से कट जाने पर चींटे को इस घाव के दोनों हिस्सों को पकड़ाकर उसका सिर काट दिया जाता था जिससे चींटे का सिर टांके  की तरह काम करता था। यह तरीका आज भी आदिवासियों एवम आदिम जनजातियों में प्रयोग में लिया जाता है ।
4.चरक ऋषि चीरा लगाते समय अनावश्यक रक्तस्राव  को रोकने के लिए विषहीन जोंक का उपयोग किया करते थे ।जिससे आवश्यक चीरा बिना किसी व्यवधान के लगाया जा सके।
5. विष हीन जोंक का उपयोग दूषित रक्त को शरीर के किसी भाग से निकालने के लिए किया जाता था ।
    कालांतर में यूरोप में पुनर्जागरण के परिणाम स्वरूप अध्ययन क्षेत्र का प्रचार प्रसार हुआ जिसके कारण ऐसे रोगों के उपचार के तरीके खोजे जाने लगे जो अभी तक लाइलाज थे । इसी क्रम में लुइस पाश्चर ने जीवाणु सिद्धांत की खोज की । एडवर्ड जेनर ने टीके का निर्माण किया। सर रोनाल्ड रॉस ने मलेरिया परजीवी के जीवन चक्र को समझाया। 
   इन सभी के कारण स्वच्छता की महत्ता का विकास हुआ जिसका प्रयोग सुश्री फ्लोरेंस नाइटिंगेल ने क्रीमिया युद्ध (1853) में कर अनेक सैनिकों की जान बचाई।

रोग उत्पति की विचारधाराएं

रोग उत्पति की विचारधाराएं 
1 पाश्चर का जीवाणु सिद्धान्त 
पासवर्ड ने जवानों सिद्धांत प्रतिपादित किया जिसके अनुसार किसी रोग की उत्पत्ति का कारण सुख समझे होते हैं जो किसी दूसरे जीव या माध्यम से व्यक्ति में प्रवेश कर जाते हैं एवं रोग उत्पन्न करते हैं जैसे प्रोटोजोआ जवानों का वक्त वायरस इत्यादि इसी दांत ने अन्य सभी सिद्धांतों की तुलना में मेडिसन के विकास में बहुत अधिक योगदान दिया है इसी कारण स्वच्छता का उपचार में समावेश किया गया एवं तीता एसएक्सेस का विकास हुआ यह ही वह मुख्य विंडो था जिसके कारण हम आगे बढ़ पाए।
2 दैवीय प्रकोप विचार धारा
इस विचारधारा अनुसार रोग या बीमारी मनुष्य को प्रकृति या दैवीय शक्तियों द्वारा दिया गया दंड है जो कि उसके गलत कर्मों के कारण उसे दिया गया है । इसके उदाहरण मिश्र  की मेसोपोटामिया एवं भारत की मोहनजोदड़ो हड़प्पा सभ्यता में मिलते हैं जहां विभिन्न पूजा एवं बली स्थल इस विचारधारा के पक्ष में प्रमाण प्रस्तुत करते हैं । 
   आज भी आदिम कबीलों में यहां तक कि गांव में किसी रोग के उपचार के लिए रोगी को स्थानीय देवी या देवता के पास ले जाया जाता है। एवं झाड़ा फूंक से उसका  उपचार  किया जाता है ।
      जैसे आज भी जैसे सांप के काटने पर स्थानीय देव के मंदिर में जाना । घर में गंभीर बीमारी होने पर पारिवारिक पूर्वजों को बुलाना एवं पूजा करना इत्यादि।
3 जैव चिकित्सीय विचार धारा:-
जीव विज्ञान में सूक्ष्मदर्शी का आविष्कार ,हार्मोन ,एंजाइम कार्बोहाइड्रेट , प्रोटीन की खोज ने जैव - रासायनिक क्रियाओं को समझने में सहायता की। इन क्रियाओं को समझने के साथ-साथ यह भी ज्ञात हुआ कि इनकी कमी या अधिकता के कारण भी रोग उत्पन्न होते हैं । 
*कार्बोहाइड्रेट की कमी से हाइपोग्लाइसीमिया और अधिकता से हाइपोग्लाइसीमिया, (डायबिटीज)। 
*प्रोटीन की कमी की वजह से क्वाशियोरकर ,मेरास्मस,इत्यादि।
*एंजॉइम विकार की वजह से पाचन में दूध जन्या पदार्थों से एलर्जी होना ।
*हार्मोन विकार से कुशिंग सिंड्रोम, हाइपो या हाइपर थाइरॉएडिज्म आदि
4 बहु कारण विचारधारा:-
 उपरोक्त विचारधारा के एकीकरण के परिणाम स्वरूप इस विचारधारा का विकास हुआ एवं यह माना गया कि रोग उत्पत्ति का कोई निश्चित कारण नहीं होता है। रोग अनेक प्रकार के होते हैं। उसी प्रकार उनके कारण भी अलग-अलग होते हैं । एवमं रोग उत्पत्ति का कोई सर्वमान्य एकल कारण नहीं है बल्कि रोग उत्पत्ति के अनेक कारण हो सकते हैं यहां तक कि एक ही रोग उत्पन्न होने के कई कारण एक साथ जिम्मेदार हो सकते हैं उदाहरणार्थ  पीलिया होने के कारण अमन हो सकते हैं:-
* हेपेटाइटिस 
*एनीमिया 
*एंजॉइम विकार 
*विषाक्तता 
*पोषण संबंधी कारण
5 मनो- सामाजिक विचारधारा:-
 जब 'स्वास्थ्य ' में सामाजिक एवं मनोवैज्ञानिक की स्वस्थता को शामिल किया जाने लगा तो इनसे संबंधित कारण या परिस्थितियां भी रोग उत्पत्ति का कारण मानी गई । एवं उन्माद अवसाद या सिजोफ्रेनिया जैसे रोगों का कारण पारिवारिक कलह , विषाद, हीन भावना ,गरीबी ,लांछन ,सही देखभाल या लालन पालन न होना माने गए।
 वर्तमान में 'स्वास्थ्य ' की अवधारणा के बहुआयामी होने के कारण इन सभी को रोगों की उत्पत्ति का कारण माना जाता है। इसे 'आधुनिक विचारधारा' भी कहा जा सकता है।

Sunday, 19 April 2020

सबक सिखा रही कोरोना वायरस

      बहुत से सबक सिखा रही कोरोना वायरस -- एक सबक यह भी जन स्वास्थ्य के बारे में ----
          भविष्य की दुनिया की  व्यवस्था में शायद जन स्वास्थ्य सेवा नीति निर्धारक बहस की आधारशिला के रूप में उभरेंगे । पिछले कुछ दशकों में दुनिया की  व्यवस्था स्वास्थ्य सोवा ढांचे के छोटा होने, विनिवेश होने और नीजिकरण की साक्षी है जिसने कि स्वास्थ्य सेवाओं के व्यवसायिकरण की राह को ही आगे बढ़ाया है । महामारी के इस संकट में जब वो देश जिसके पास मजबूत जन स्वास्थ्य सेवा प्रणाली है जिसमें चीन, सिंगापुर और ताइवान शामिल हैं ने महामारी पर प्रभावी तरीके से काबू पा लिया तो वहीं जिनकी स्वास्थ्य सेवा प्रणाली बाजार आधारित थी जैसे अमेरिका और यूरोपीय यूनियन वे बुरी तरह से तबाह हो गये।
          यहीं पर केरल की स्वास्थ्य सेवा प्रणाली वैश्विक रूप से प्रासंगिक हुई है।
          केरल ने महामारी पर प्रभावी तरीके से काबू किया है, सक्षमता से सार्वजनिक एक्शन के उपयोग, जन केन्द्रीत स्थानीय प्रशासन, और व्यापक राजनीतिक चेतना के माध्यम से जिसने राज्य के सामाजिक परदिृश्य को परिभाषित किया है। भविष्य की वैश्विक व्यवस्था में स्वास्थ्य को एक बुनियादी अधिकार और एक वैश्विक सार्वजनिक वस्तु की तरह लिया जायेगा। 
         इसमें  कोई दो राय नहीं कि स्वास्थ्य का उत्पादन नही किया जा  सकता है और उसे कामेडिटी की तरह बेचा भी नही जा सकता है। हालांकि विश्व स्वास्थ्य संगठन ने स्वास्थ्य को एक सार्वजनिक वस्तु की अवधारणा को मान्यता दी है और विश्व बैंक उससे पहले ही ऐस कर चुका है, फिर भी मौजूदा संकट फिर से पूरी दुनिया में इस अवधारणा को जिंदा कर रहा है। स्वास्थ्य के एक सार्वजनिक वस्तु की अवधारणा के साथ ही इसमें राष्ट्र राज्य की भूमिका पर और इसकी नैतिक जिम्मेदारी पर भी पुनर्विचार होगा। इस उभरते हुए रूझान के दो आयाम हैं। इनमें से एक है  शिक्षा, स्वास्थ्य, विज्ञान, प्रोद्यौगिकी और सामाजिक सुरक्षा में अधिक निवेश के साथ एक कल्याण राज्य के मॉडल को पुनर्जीवित करना। हम फैलती हुई महामारी को प्रभावी तरीके से नियंत्रित करने में बाजार राज्य के मॉडल की नाकामी को देख चुके हैं। पॉल मेसोन के अनुसार यह एक ऐसे कल्याण राज्य की जरूरत को बना सकता है जिसका फोकस सामाजिक न्याय, समानता और सार्वजनिक वस्तुओं के समान वितरण पर हो सकता है। 

संकट के घने बादल--1

                संकट के घने बादलों के बीच से ही उम्मीद की किरण दिखाई देती  है, यह विश्वास ही वह ताकत देता  है जिसके साथ हम हर चुनौती का सामना करते आये  हैं । आज भूख, अभाव और एक भयानक महामारी की ही सिर्फ विकराल छाया हमें घेरे हुए नहीं है , बल्कि आने वाले दिनों में जिन्दगी काफी मुश्किल में होने जा रही है । पूरे देश में कॉल डाउन ने  जहाँ कुछ राहत दी साथ ही वहीँ समस्याएं भी बहुत खड़ी की हैं |  यह  संकट अभी तक चल रही परिस्थितियों की विषमताओं में और विकराल रूप धारण करने वाला है। 2016 के आर्थिक सर्वे के मुताबिक  77 प्रतिशत लोग किसी तरह जिन्दा रहने की कोशिश में रहते रहे हैं, वे प्रतिदिन की दिहाड़ी से सिर्फ भूख से छुटकारा पाने की कोशिश करते हैं-उनके पास बचता कुछ भी नहीं है। कैशलेस, यानी बिना पैसे के ही चल रही  है उनकी जिन्दगी। उन्हें बैंक से कोई कर्ज भी नहीं मिल सकता। किसी भी बड़ी जरूरत को पूरा करने के लिये बड़ी  ब्याज दर पर ही उनको  उधार मिल पाता  हैं और इस  ब्याज को ही चुकाने में ही उनकी  जिन्दगी गुजर  जाती है। आज भविष्य भी अंधकार में ही डूबा दीख रहा है, क्योंकि  लॉकडाउन के बाद वापस आने पर उनके वेतन में तो कटौती होगी ही, जो वेतन मिला नहीं, उसकी भी उम्मीद खत्म हो चुकी है। आज 1.3 बिलियन की जनसंख्या में, पूरा एक बिलियन, जो असंगठित क्षेत्र में है, उसका बुरा हाल है । ऐसी स्थिति में महामारी और उसके साथ तालाबंदी से आर्थिक स्तर तो उनका मुश्किल में आ ही चुका है, उत्पादन के सारे क्षेत्रों में भी ठहराव है।   यह जरूरी है कि सरकार को आज पूरी ताकत से अपनी सारी श्रम शक्ति ( गहराते संकट के बीच इस  मेहनतकश जनता) को बचाना ही होगा। आज पूरी व्यवस्था के सामने जो चुनौती है उसे इस  मजदूर तबके के बिना पराजित करना संभव नहीं है , जो समाज में अपनी हर जरूरत के लिये मोहताज रहता है। यह आज सिर्फ भारत की ही नहीं पूरे विश्व की स्थिति है। 
            इसलिये सरकार को, अभाव से जूझती इस जनता को कैश देना होगा, अलाउन्सेज देने होंगे, अगर वे बेरोजगार हैं तो समुचित स्वास्थ्य सुविधा, आर्थिक सहयोग और टैक्सों में छूट देनी होगी। 
जनता की क्रयशक्ति, को फिर से जीवित करने के लिये यह सब भी जरूरी है। लघु और मध्यम स्तर के उद्योग जो पिछले कई वर्षों से विषम कठिनाईयों से जूझते रहे हैं, बिखर भी चुके हैं, इन सबको फिर से जीवित करना होगा। उनकी  समुचित आर्थिक आपूर्ति करनी होगी। 
        इस संकट में सबसे बड़ी समस्या भूख की है-और भोजन जुटाने के लिये कृषि व्यवस्था को उबारना बहुत जरूरी होगा। जन वितरण व्यवस्था से राशन का वितरण भी होता है। फूड कॉरपोरेशन ऑफ इंडिया के पास 77 मिलियन टन अनाज भरा पड़ा है, इसलिये इस अनाज को जनता में बांटने के लिये एफसीआई के गोदामों को खोल देना चाहिये। लेकिन वास्तविकता यह है कि जो छह किलोग्राम अनाज राशन में मुफ्त में बांटने का निर्णय है, उसके लिये भी राज्यों से पैसा मांगा जा रहा है। आर्थिक संकट की लगातार उपेक्षा के नतीजे भी सामने आ रहे हैं। 22 मार्च के बाद से बेरोजगारी में तिगुनी बढ़ोतरी हुई है। यह 8.7 प्रतिशत से 23.4 प्रतिशत तक और फिर 5 अप्रैल तक 30.9 तक पहुंच चुकी है। ग्रामीण क्षेत्रों में यह आज 20.2 प्रतिशत है। इस तरह पूरे देश में यह बेरोजगारी, सेन्टर फॉर मॉनिटरिंग इकोनोमी की रिपोर्ट के अनुसार 23. 4 तक पहुंच चुकी है। हमारे देश में वेतनभोगी मजदूरों की संख्या बहुत ही कम है, सिर्फ 22.1 प्रतिशत। बाकी के 78 प्रतिशत अमानवीय परिस्थितियों में, बिना किसी सामाजिक सुरक्षा के काम करते हैं यही वह मजदूरों की विशाल जमात है, जो अपने घरों की ओर, सैकड़ों मील पैदले चले जा रहे हैं, जहां भूख और बेरोजगारी का एक नया दौर उनकी प्रतीक्षा कर रहा है। बेरोजगार, बेसहारा और भूखी यह जनता ही देश की वह ताकत है जो देश को समृद्धता देती है, ओर समाज को आगे
ले जाती है। आज यह सत्य क्रमशः विश्व के सामने उजागर हो रहा है, जिसे किसी भी तरह अनदेखा नहीं किया जा सकता। इस संकट ने पूरी व्यवस्था को एक नया आयाम दिया है, जो दक्षिणपंथी सोच की निरर्थकता को सामने ला रही है।